What are organ-specific autoimmune disease?
In autoimmunity. An organ-specific disease is one in which an immune response is directed toward antigens in a single organ. Examples are Addison disease, in which autoantibodies attack the adrenal cortex, and myasthenia gravis, in which they attack neuromuscular cells.
What autoimmune disease can be detected during a blood test?
It is usually used to diagnose rheumatoid arthritis, but it can also detect juvenile arthritis, lupus, certain infections like tuberculosis, some types of cancer such as leukemia, and other autoimmune disorders.
What does it mean if my ANA IFA is positive?
In most cases, a positive ANA test indicates that your immune system has launched a misdirected attack on your own tissue — in other words, an autoimmune reaction. But some people have positive ANA tests even when they’re healthy.
Is Sjogren’s organ-specific?
It was found that in addition to a clinical manifestations Sjogren’s syndrome is characterized by existence of a wide range of organ-specific and organ- nonspecific autoantibodies that is a consequence of polyclonal uncontrollable activation of the immune system.
What can trigger an autoimmune disease?
The exact cause of autoimmune disorders is unknown. One theory is that some microorganisms (such as bacteria or viruses) or drugs may trigger changes that confuse the immune system. This may happen more often in people who have genes that make them more prone to autoimmune disorders.
How do you rule out an autoimmune disease?
“There’s usually no single test to diagnose autoimmune disease. You have to have certain symptoms combined with specific blood markers and in some cases, even a tissue biopsy. It’s not just one factor.” Diagnosis can also be difficult because these symptoms can come from other common conditions.
Which blood test is an indicator of the presence of an inflammatory disease?
Inflammation and blood proteins Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and plasma viscosity (PV) blood tests are commonly used to detect increase in protein in the blood. In this way they are used as markers of inflammation.
Is Sjogren’s syndrome serious?
Complications of Sjögren’s syndrome Sjögren’s syndrome can sometimes lead to complications. For example, your eyesight could be permanently damaged if the reduced tear production isn’t treated. Sjögren’s syndrome also increases your risk of developing non-Hodgkin lymphoma, which is a cancer of the lymph glands.
What are some examples of autoimmune diseases detected with this test?
Examples of autoimmune diseases detected with this test include: 14 1 Chronic inflammatory demyelinating polyneuropathy 2 Guillain-Barré syndrome 3 Immune thrombocytopenic purpura 4 Myasthenia gravis 5 Sjogren’s syndrome
What is the role of lab testing in the evaluation of autoimmune diseases?
Laboratory testing is of great value when evaluating a patient with a suspected autoimmune disease. The results can confirm a diagnosis, estimate disease severity, aid in assessing prognosis and are useful to follow disease activity.
What is the hallmark of autoimmune disease?
I. Introduction. Autoimmunity involves the loss of normal immune homeostasis such that the organism produces an abnormal response to its own self tissue. The hallmark of autoimmune diseases generally involves the presence of self-reactive T cells, autoantibodies and inflammation.
What are the clinical entities of autoimmune thyroid diseases (aitds)?
The clinical entities found in AITDs are diverse and vary depending on whether a state of hypothyroidism (HT), hyperthyroidism (GD), or both [Painless thyroiditis (PT), Postpartum thyroiditis (PPT), and Subacute thyroiditis (SAT)] predominate in the patient (7) (Table 2). Table 2 Main characteristics of autoimmune thyroid diseases.