What is mucinous metaplasia?
Mucinous metaplasia is an uncommon type of endometrial epithelial metaplasia, often associated with hyperestrogenic states or hormone replacement therapy. Histologic findings range from simple endocervical-type mucinous epithelium to architecturally complex mucinous proliferations.
What is metaplasia of endometrium?
Endometrial epithelial metaplasia refers to the replacement of the normal endometrial glandular epithelium by cells that are either not encountered in the normal endometrium or, if present, are usually inconspicuous elements.
Is endometrial metaplasia precancerous?
It is generally known that endometrial tubal metaplasia is a benign disease. However studies propose endometrial tubal metaplasia to be a potential premalignant endometrial lesion and its association with endometrial hyperplasia and well-differentiated endometrioid carcinoma.
What is the most common histologic form of endometrial cancer?
Endometrioid carcinoma is the most common histologic type of endometrial carcinoma and of uterine malignancy overall. Endometrioid tumors tend to have a favorable prognosis and typically present at an early stage with abnormal uterine bleeding.
What is papillary metaplasia?
Although simple mucinous metaplasia is characterized by simple, round glands lined by tall columnar mucinous epithelium, papillary mucinous metaplasia has intraglandular papillary projections with or without fibrovascular cores, or complex glandular architecture at the periphery of cystically dilated glands producing …
How is squamous metaplasia treated?
Conclusion: The therapeutic management of keratinizing squamous metaplasia is controversial, and currently no effective medical therapy is available for its treatment. Actually, patients undergo transurethral resections and a multidisciplinary approach is required to avoid cystectomy.
How serious is endometrial hyperplasia?
When the endometrium, the lining of the uterus, becomes too thick, it is called endometrial hyperplasia. This condition is not cancer, but in some cases, it can lead to cancer of the uterus.
What is the difference between endometrial cancer and uterine cancer?
Endometrial cancer begins in the layer of cells that form the lining (endometrium) of the uterus. Endometrial cancer is sometimes called uterine cancer. Other types of cancer can form in the uterus, including uterine sarcoma, but they are much less common than endometrial cancer.
What is squamous metaplasia of endometrium?
Squamous metaplasia is one of the most common metaplastic changes to involve the endometrium. It may be seen in association with a variety of histologic changes, ranging from benign reactive processes (e.g., chronic endometritis, intrauterine devices, and trauma) to adenocarcinoma.
What is the treatment for disordered proliferative endometrium?
The most common treatment is progestin. This can be taken in several forms, including pill, shot, vaginal cream, or intrauterine device. Atypical types of endometrial hyperplasia, especially complex, increase your risk of getting cancer. If you have these types, you might consider a hysterectomy.
Is papillary mucinous metaplasia a precancerous lesion in endometrial carcinoma?
No PTEN mutations were observed in either of the two groups. In conclusions, immunohistochemical and molecular genetic profiling suggest that papillary mucinous metaplasia is a possible precancerous lesion in a subset of endometrial carcinomas. Adenocarcinoma, Mucinous / chemistry
What is papillary proliferation metaplasia in endometrium?
Papillary Proliferation Metaplasia in Endometrium is a type of metaplasia noted in the uterine corpus. It is diagnosed by a pathologist on examination of endometrial tissue under a microscope. What are the other Names for this Condition? (Also known as/Synonyms) Metaplasia of Uterus, Papillary Proliferation Type
What are the signs and symptoms of endometrial mucinous metaplasia?
Generally cytologically bland but can obscure examination of the glandular architecture Extensive replacement of surface endometrium with mature, keratinizing, squamous epithelium as a result of chronic inflammation or cervical obstruction Mucinous metaplasia may be found in the ovaries or cervix of patients with endometrial mucinous metaplasia
Does mucinous metaplasia mean neoplasia?
Mucinous metaplasia sometimes shows patterns equivalent to a diagnosis of endometrial intraepithelial neoplasia (EIN) [1]. These patterns include a florid papillary architecture or papillary mucinous, ciliated or mucus-producing ciliated epithelium in the endometrial glands.